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2.1.3.6 Treating DN by TCM herbs or extracts A meta-analysis of 18 randomized controlled trials on senile diabetic nephropathy (DN) identified Astragalus, yam, and Cornus officinalis as the most frequently used TCM herbs for DN treatment

There are two main ways to avoid excessive interaction of the gut microbiota with TLRs to prevent activation of the intestinal and in some cases systemic immune response: i) decreasing the expression of TLRs, and ii) moving TLRs from the plasma membrane into lysosomes (Semin et al., 2021)