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Discipline Over Speed 5

Excessive ROS not only causes DNA damage and genetic instability but also affects immune metabolism pathways, weakening the immune systems normal function, thus promoting cancer development and progression as well as cellular aging and tissue function decline 96

TNF- activates multiple signaling pathways through binding to its receptors (TNFR1 and TNFR2), inducing the release of inflammatory mediators, cell proliferation, apoptosis, and immune cell recruitment, ultimately leading to chronic intestinal inflammation

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Effects of Bugu Shengsui decoction on related indicators of oxidative stress and Ferroptosis in rats with osteoporosis