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PMID: 40959268 Int J Biol Sci Timosaponin AIII promotes non-small-cell lung cancer ferroptosis through targeting and facilitating HSP90 mediated GPX4 ubiquitination and degradation

108, 118 This is not surprising, given that the species-specific diet in mice is very different from humans who are omnivores and during much of their evolution consumed low-glycemic load diets

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164 Furthermore, an isocaloric diet that moderately reduced protein intake (by 25%) was shown to trigger an unfolded protein response (UPR) that depended on IRE1 in cancer cells

Similarly, Human astrocytes (ScienCell #1800) were plated in triplicate at a density of 6000 cells per well in a 96-well plate