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(1) Omega-3 PUFAs (EPA/DHA) as core antidepressant components Deep-sea fish (e.g., salmon, mackerel) contain 23 g/100 g of EPA and DHA, which target two key pathways of depression: Inhibiting microglial activation: by inhibiting the NF-B/MAPK p38 signaling pathway and activating the neuronal BDNF-PI3K/AKT pathway, the process achieves a balance in microglial M1/M2 polarization and provides neuroprotection against neuroinflammation (313)

117157, doi:10.1016/b978-0-443-13231-5.00018-0, ISBN 978-0-443-13231-5 1 2 The Chlamydomonas Sourcebook , Elsevier, pp

RobinsonMGraySRWatsonMSKennedyGHillABelchJJFet al

The right dosage depends on individual factors such as age, lifestyle, environmental exposure, and health goals

It biochemically represents various signaling pathways, such as kinase-mediated necroptosis, gasdermin-mediated necrosis downstream of inflammasomes, and an iron-catalyzed mechanism (14, 19, 20)