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The treatment of PFIC has long been based on the use of drugs, such as ursodeoxycholic acid (UDCA), rifampicin, and cholestyramine, or surgical biliary diversion (SBD), aimed at reducing symptoms, especially pruritus [13]

At physiological pH and 0.3 mM concentration, ureate, an ionized form of UA, scavenges 1 O 2 species

Dihexa binds to HGF and potentiates its activity at the c-Met receptor on neurons

Materials and methods Caviar and roe samples Experiments were conducted under approval of the Ethics Committee for the use of animal subjects, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt (approval number REC 413)

Since crystalline substances generally dissolve more slowly than amorphous ones, this crystalline behaviour may influence the release kinetics of letrozole