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Neither is FDA-approved

Regarding AR-V7, its expression was increased in the xentuzumab + enzalutamide group compared with the enzalutamide-only group (Weyer-Czernilofsky et al., 2020)

Proper monitoring ensures that treatment remains within safe physiological limits

These gaps highlight the need for future research to move beyond single-cell type and descriptive mechanisms toward systematic dissection of intercellular crosstalk, renal parenchymal cell contributions, and clinical validation