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In animal models, 1-methyl-4-phenol-1,2,5,6-tetrahydropyridine (MPTP) is used to induce destruction of dopaminergic neurons in the substantia nigra, mimicking human Parkinsons-like syndrome (111), while the infusion of BHB was found to have a protective role in dopaminergic neurodegeneration and motor deficits induced by MPTP (112)

Synergistic anti-inflammatory effects and mechanisms of combined phytochemicals

Acknowledgements The authors thank Debra Weingarten for her editorial assistance in the preparation of this manuscript

Bojungikgi-Tang was shown to significantly inhibit A and BACE1 activity, enhancing cognitive performance in A njected ICR mice

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