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J Biol Chem 208: 4153

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doi: 10.3390/ijms150712895 [DOI] [PMC free article] [PubMed] [Google Scholar] 152.Poncin S, Grard AC, Boucquey M, Senou M, Calderon PB, Knoops B, et al

Within the cyst(e)ine/GSH/GPX4 axis, cysteine is the rate-limiting metabolite for GSH biosynthesis, hence the ferroptosis-inducing activity of cyst(e)ine depletion has largely been attributed to the lowering of intracellular GSH levels and subsequent decrease of GPX4 activity