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PLoS One 9, e91848

The effects of metformin, a first-line medication for type 2 diabetes, on OA and its underlying mechanisms remain obscure

Brit J of Exp Pathol 57,15764

Sci Rep (2016) 6:20176

Gastric acid production naturally increases during overnight fasting periods, making conditions like GERD and gastritis more likely to cause pain upon waking when the stomach is most acidic