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10.18433/j3nc79 122 PivinaL.SemenovaY.DoaM

The latest development in the lupus research field is chimeric antigen receptor (CAR) T-cell therapy, which has been studied extensively in people with cancer

Notably, heterozygous EPAS1 knockout mice recapitulate the Tibetan phenotype of attenuated hemoglobin elevation and confer protection against chronic hypoxic injury [11], providing direct experimental validation for our focus on EPAS1 downregulation in Tibetan high-altitude adaptation