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Therefore, the HGF/c-Met axis is a key player in cell proliferation, survival and migration and, when dysregulated, can give origin to a variety of cancers

a , Viability of FBXL5 KO cells or FBXL5/PRDX6 double knockout cells treated for 24 h with FAC (50 or 100 g ml -1 ), and immunoblot analysis of lysates from the indicated cells