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MazF ribonucleases promote Mycobacterium tuberculosis drug tolerance and virulence in guinea pigs

doi: 10.1016/j.expneurol.2008.04.009 71 DeuisJ

This S- modification was thought to physically block substrate access to the catalytic site (Chen et al., 2013)

As granulomas mature, they develop fibrous walls and experience a significant decrease in the number of vessels penetrating the structure, which hampers the penetration of anti-TB drugs into the necrotic and hypoxic areas of the granuloma, where M.tb persists [98, 99]

Most people notice initial effects within the first few weeks, with more significant results appearing over several months