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Muller HL, Emser A, Faldum A, Bruhnken G, Etavard-Gorris N, Gebhardt U, et al

In a maintenance trial, nausea affected 47% of participants during escalation but fell to 14% after the same 2.4 mg dose was held. Receptor exposure stayed constant

In humans, exercise induces the expression of MOTS-c in skeletal muscle and circulation, indicating its role as an exercise-induced regulator of physical capacity and metabolic homeostasis 6