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Aloe-emodin reverses adriamycin (ADR) resistance in MCF-7/ADR cells by inhibiting P-gp efflux, altering energy metabolism, and inducing autophagy while enhancing apoptosis via DNA damage, ROS generation, and Caspase-3 activation [504]

A Health Department spokesperson said, "the TGA has not considered the use of glutathione for skin lightening/whitening purposes

Nevertheless, lesional CTLs are not the only cells that activate the CCL5CCR5 axis: In vitiligo, CCR5 expression is elevated on regulatory T cells (Tregs), indicating that (dysfunctional) Tregs may be involved in skin depigmentation