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PubMed, doi:10.1093/carcin/bgm300.Butts, Samantha F., et al

doi: 10.1016/j.fct.2014.11.025, 88

But knowing the half-life helps you avoid accidental problems, like mixing Vyvanse with alcohol, which can be risky

Zhang Q, Bykov VJN, Wiman KG, Zawacka-Pankau J

363 In contrast, secondary resistance arises after an initial period of therapeutic efficacy, during which tumors gradually acquire resistance under ongoing selective treatment pressure, ultimately leading to disease progression or reccurence