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This was associated with reduced expression of xCT (the catalytic subunit of Sxc ) and mGlu2 receptors [116], suggesting that a defective endogenous activation of mGlu2 receptors in the nucleus accumbens underlies the altered glutamate homeostasis that is ultimately responsible for the loss of control in drug-seeking behavior and relapse

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It is important to keep in mind that these alterations occur in the normal aging brain, but are exacerbated in neurodegenerative diseases like Alzheimers disease (Papu and Rejdak, 2020)

In the presence of BSO, GA had no positive effect on the MMP (Fig