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Inhibit osteoclast activation and differentiation, reduce bone resorption Block osteoclast differentiation signal RANKL/RANK/OPG pathway: AOD 9604 downregulates the expression of RANKL (a key factor in osteoclast differentiation) and upregulates the expression of OPG (a RANKL antagonist), reducing the RANKL/OPG ratio by 50-60% and blocking the differentiation of osteoclast precursors into mature osteoclasts

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As previously discussed, mutagenesis studies revealed that these residues are important for the NADase activity of human CD38, and changes in these residues led to the abolishment of the glycohydrolase activity and to an increase in the cyclase activity

Week 4 Repeat of Week 1 and 2