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Additionally, GLPs lower plasma nitric oxide (NO) levels by inhibiting the mRNA expression of inducible nitric oxide synthase (iNOS), thereby alleviating oxidative damage and safeguarding pancreatic cells (Xie et al., 2020)

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Lipid peroxidation, the executioner of ferroptosis, holds an undeniable role in the pathogenesis of BD

In the following years, studies revealed a significant decrease of complex I activity in the SN of patients with idiopathic PD [83, 84], as well as reduced activity of complexes I and IV in peripheral blood [85]