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It is not fair to demonize Metformin over this issue

If youre experiencing redness, swelling, bruising, or a little bleeding, thats not uncommon

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Prior trauma exposure, including early life trauma, is associated with altered 5-HT receptor expression, particularly 5-HT 1A receptors, which may alter subsequent risk of mood and trauma-related disorders (91)

Penicillamine can have severe side effects that include bone marrow suppression, blood disorders, kidney disease, and kidney failure (NLM 2012