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The mechanisms most relevant to knee pain: VEGF upregulation stimulates new blood vessel formation in cartilage and connective tissue, areas that are notoriously slow to heal due to limited blood supply Nitric oxide modulation regulates inflammation and promotes vasodilation, improving blood flow to damaged tissue Collagen synthesis accelerates organized collagen deposition at repair sites instead of disorganized scar tissue Tendon-to-bone healing particularly relevant at the patella tendon and other knee attachment points Animal studies across rat, rabbit, and canine models showed consistent findings across these pathways

De Oliveira, A

Refrigerate after reconstitution and use within 30 days

UVB: 312 nm, 0.91 mW/cm 2 , 0.08 J/cm 2 ) in human epidermal keratinocytes (ScienCell) 178

More efforts on both development of materials engineering and biomedicine are needed to bridge the gap