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Although CSCs are similar to stem cells in terms of function, because of the lack of a negative feedback regulation mechanism for stem cell self-renewal, their powerful proliferation and multidirectional differentiation abilities are unrestricted, which allows CSCs to maintain certain activities during chemotherapy and radiotherapy [[90], [91], [92]]

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One investigation on dietary interventions (57) in healthy subjects divided into a VEG group (usual dietary regimen + 4 servings of vegetables) and an FMD group (5-day hypocaloric diet) established that the plasma TMAO, fasting blood glucose, and C-peptide of subjects in the FMD group diminished considerably compared to the VEG group

Second, follow-up periods were predominantly short-term, focusing on immediate postoperative outcomes