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R 2 is selected from the group consisting of: hydrogen, ~ HPO(OY) 2 , " * ~ PO(OH) 2 , and - C(=0)-Y, where Y is -Z-(CH 2 )q-W-R b , q is 0-4, where Z and W are independently selected from the group consisting of: CH2, O, S, R C and R b , where R c is selected from the group consisting of: hydrogen, C1-C4 alkyl, and C3-C6 cycloalkyl, R b is selected from the group consisting of: hydrogen, C1-C12 alkyl, C1-C12 substituted alkyl, C3-C8 cycloalkyl, C3-C8 substituted cycloalkyl, C3-C8 heterocycloalkyl, and C3-C8 substituted heterocycloalkyl

this is due to the increase in size of the boron atoms atomic radius compared to carbon, as well as the fact that boron has a weaker bond strength than carbon

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(You can read more about iodine, and the different views on iodine supplementation in Hashimotos, in my article on iodine and Hashimotos .) If you do have an adverse reaction to selenium (again, this is very rare), you may find that you have an iodine deficiency

Additionally, while this review proposes mechanisms linking potential mitochondrial dysfunction to specific hEDS symptoms such as fatigue, connective tissue fragility, and gastrointestinal dysmotility, the exact molecular pathways remain poorly defined