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Structure 25(6):945950 Zhang R et al

The results demonstrated that BV2-metformin-loaded PLGA treatment reduced TNF- and GFAP expression, confirming suppression of neuroinflammation, while p62 levels were increased, indicating enhanced autophagy

Any disruption to BBB integrity can lead to altered cerebral function, contributing to different neurological diseases, including cognitive dysfunction (Ronaldson and Davis, 2020