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Poster Session I - RISK FACTORS - PRIMARY AND SECONDAR PREVENTION 05.00 - RISK FACTORS AND PREVENTION (PRIMARY AND SECONDARY) - 05.03 - EPIDEMIOLOGY & RISK FACTORS P415 - ESOC25-2100 HIGHER STROKE RECURRENCE IN ESUS PATIENTS WITH EXTENSIVE WORKUP AND NO IDENTIFIABLE MECHANISM: ANALYSIS FROM THE CASPR STUDY Farhan Khan 1 , Christoph Stretz 1 , James Siegler 2 , Debora Kerrigan 3 , Kelsey Eklund 4 , Hassan Aboul Nour 5 , Richa Sharma 6 , Sami Al Kasab 7 , Christina Lineback 8 , Farid Khasiyev 9 , Emiliya Melkumova 10 , Malik Ghannam 11 , Dinesh Jillella 12 , Yasmin Aziz 13 , Shadi Yaghi 1 1 Brown University, Providence, United States, 2 University of Chicago, Chicago, United States, 3 Vanderbilt University, Nashville, United States, 4 University of Colorado, Colorado, United States, 5 University of Kentucky, Lexington, United States, 6 Yale University, New Haven, United States, 7 MUSC, Charleston, United States, 8 University of Michigan, Ann Arbor, United States, 9 Columbia University, New York, United States, 10 Tufts Unnveristy, Boston, United States, 11 University of Iowa, Iowa City, United States, 12 Emory University, Georgia, United States, 13 University of Cincinnati, Cincinatti, United States Background and Aims: The minimum diagnostic evaluation outlined by the ESUS construct may not adequately exclude mechanisms that could alter management (e.g., PFO or device-detected AF)