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doi: 10.1016/j.celrep.2021.109447 [DOI] [PMC free article] [PubMed] [Google Scholar] 18

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Medication may reduce nerve excitability, but pain can continue if there is ongoing vascular compression, peripheral branch irritation, dental-related nerve trauma, postherpetic nerve injury, muscle spasm, scar tissue, local inflammation, or central sensitization