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10.1038/s41467-025-59826-8 Nat

Most of these responses depend on the transactivation of epidermal growth factor receptor (EGFR) and its downstream targets phosphoinositide 3-kinase (PI3K)/serine-threonine-specific protein kinase B (also known as Akt) and extracellular signal-regulated kinases 1/2 (ERK 1/2) signaling pathways (Figure 2