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Methods: SACRED is a phase III, prospective, multi-center, double-blind clinical trial (NCT03654053) that enrolled patients with compensated cirrhosis and clinically significant portal hypertension (CSPH), stratified upon concomitant use of nonselective beta-blockers, randomized enrollees 1:1 to simvastatin 40 mg/day versus placebo for up to 24 months at 11 Veterans Affairs Medical Centers in the United States

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Sleep and Vigilance 3(2):121129 Cho HJ et al (2017) Sleep disturbance and kynurenine metabolism in depression

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Integrated multiomics analyses with experimental validation in myotubes and muscle tissue with loss and gain of function show Hif1- and ammonia-dependent and independent changes during physoxia