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Conclusion Our study reveals the PKC/-ARR2 axis as a key molecular mechanism that disrupts SORLA retrograde trafficking and drives its degradation

The flow cytometry analysis showed that affinity cell sorting with GST-EGFP-GPI DAF , GST-EGFP-GPI BY55, and GST-EGFP-GPI CEAM7 significantly increased the EGFP positive cell ratio in both Lenti-X 293T and K-562 cells (Figures 3A,B)

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