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Abdelmalek 3 , Philippe Huot-Marchand 1 , Lucile Dzen 1 , Martine Baudin 1 , Jean Louis Junien 1 , Pierre Broqua 1 and Michael Cooreman 4 , (1)Inventiva, (2)University of Antwerp, Edegem, Belgium, (3)Mayo Clinic, Rochester, MN, (4)INVENTIVA Background: A polymorphism of patatin-like phospholipase domain-containing protein 3 (PNPLA3), I148M, is strongly associated with the risk for and the progression of nonalcoholic steatohepatitis (NASH)

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Contrasting with a moderate elevation, a large increase in circulating homocysteine leads to an elevation of the plasma ratio of reduced aminothiols to total aminothiols for homocysteine and cysteine, which favors the occurrence of an antioxidant status (Andersson et al, 1995