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Rituximab has also been used to treat anti-NMDA receptor encephalitis (Ikeguchi et al, 2012) supporting a close link between autoimmunity, glutamate/GABA and encephalitis

In relationship with the pathway of negative regulation of leukocyte activation, we here found that Al-CPI upregulated the expression of cytotoxic T-lymphocyte associated protein 4 ( CTLA4 ) ( Supplementary Figure S3 ), an inhibitory receptor acting as a major negative regulator of T-cell responses

This will help elucidate the role of melatonin in shaping the immune microenvironment and its potential for combination with immunotherapies

Kelly D, Coen RF, Akuffo KO et al (2015) Cognitive function and its relationship with macular pigment optical density and serum concentrations of its constituent carotenoids

While large-scale observational studies based on climate data have provided valuable insights into the association between heat stress and milk yield losses, they often capture the combined effects of multiple environmental and management factors