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Instead of macrophages being either M1- or M2-polarized, they are mostly somewhere in between, often expressing both types of markers simultaneously ( TAMs are mainly M2-like anti-inflammatory macrophages with the ability to reduce a potent anti-tumor immune response

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In addition, the infectious burden hypothesis suggests that chronic or repeated infection may contribute to development of atherosclerosis and cardiovascular disease via hardening and narrowing of arteries over time (118)

Monocytes play a key role in recognizing BDG and governing the acute host response to infections

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