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Description

No retatrutide is an investigational triple agonist (GIP/GLP-1/glucagon) still in late-stage clinical trials as of July 2026

Also known as a growth hormone-releasing factor and GRF 1-29, it is categorized as a growth hormone secretagogue, a compound that stimulates increased secretion of growth hormone from the pituitary gland

A 2019 review in the Journal of Physiology noted that "IGF-1 signalling and mechanical loading converge on mTORC1 to regulate skeletal muscle protein synthesis, and the relative contribution of each remains an active area of investigation" [6]