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Growth Factor Gene Expression Growth factor gene expression increases substantially across multiple pathways: VEGF (Vascular Endothelial Growth Factor) Shows dose-dependent increases in mesenchymal stem cells, promoting angiogenesis and blood vessel formation bFGF (Basic Fibroblast Growth Factor) Increases 230% when combined with LED irradiation at 625-635 nm wavelengths BDNF (Brain-Derived Neurotrophic Factor) Receives stimulation for nerve outgrowth and neurological support ANGPT1 (Angiopoietin 1) Increases 487% for vascular stabilization BMP-2 (Bone Morphogenetic Protein 2) Receives upregulation for bone tissue regeneration Inflammatory Pathway Suppression Inflammatory pathway suppression occurs through multiple mechanisms

Mohammadian Khonsari N, Shahrestanaki E, Ehsani A, Asadi S, Sokoty L, Mohammadpoor Nami S, Hakak-Zargar B, Qorbani M

VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 resolution and mutational analysis of the interface