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Nevertheless, the clinical translation of L-citrulline faces significant challenges, which necessitate focused efforts to address three key issues in future research: first, current dosage recommendations are derived predominantly from animal studies, leaving the optimal supplementation dose for human subjects yet to be determined

At the family level, abundances of Enterobacteriaceae, Streptococcaceae, Clostridiaceae, Veillonellaceae, and Fusobacteriaceae increase, while those of Bacteroidaceae, Lachnospiraceae, and Ruminococcaceae significantly decline

Various rfa mutations enhanced sensitivity to antibacterial agents comparing with that of wild type S typhimurium [20]