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The evolution of dichloroacetate (DCA) as a pharmaceutical agent has a more convoluted history (202)

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Meanwhile, NNMTi preserves lean body mass: it reduces fat accumulation without causing muscle loss, which is crucial for maintaining basal metabolism and preventing weight regain after dieting.These in vivo findings fully validate the efficacy and safety of NNMTi in obesity intervention, laying a solid foundation for its subsequent clinical research and drug development

All impact simulations were performed at room temperature for 10 ps using a Berendsen thermostat with a coupling constant of 100 fs and using periodic boundary conditions

Metabolic compartments in vivo