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To overcome this challenge, efforts are being made to improve graft survival by co-transplanting with supportive cell types or neuroprotective agents [132] or employing functionalized composite scaffolds, such as those employed in mouse models of PD [133]

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The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction