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Hydroxyl radical (.OH) played a pivotal role in oridonin-induced apoptosis and autophagy in human epidermoid carcinoma A431 cells

Proc Soc Univ Surg, 2002

Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators

Under the induction of oxidative stress, a part of HIF-1 is translocated to mitochondria, where it inhibits the respiratory chain by lowering the expression of mtDNA-encoded mRNA that responses to hypoxia, thus preventing the over-production of ROS and resisting oxidative stress