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Prior to the analysis, the LFQ-intensity values were converted to percentages

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Kaede is a photoconvertible protein, which permanently changes its fluorescence emission from green (518 nm) to red (582 nm) upon photoactivation with near-UV light

Free Radic Biol Med 1995, 19 (2), 227250

Thus, the lack of CYP3A4 modulation is unlikely due to low plasma concentrations, and since the experiments were conducted under steady-state conditions after 7 days of oral administration of fluconazole, it is also unlikely that locally insufficient concentrations are behind the present observations