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The liposome-loaded hydrogel system employs liposomes as drug reservoirs and uses the extra diffusion resistance of the hydrogel to prolong drug release, suppress side effects, increase the local drug delivery concentration, and improve drug efficacy [129,130,131]

(B-F) After 24h in culture with either 250uM melatonin or vehicle control the concentrations of IL-5 (B), IL-13 (C) , IL-9 (D) IL-10 (E) , and IL-6 (F) was determined by LEGENDPlex assay