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10.1089/jmf.2022.0016 [PMC free article: PMC9700333] [PubMed: 35951019] [CrossRef] Morini G, Bassoli A, Temussi PA (2005)

bioRxiv , 2021.2010.2004.463034 (2022)

Acquired mutations in MAPK signaling pathway following initial pharmacological response in BRAF-mutated metastatic colorectal cancer (mCRC)

During randomized placebo-controlled trials in young people with cannabis dependence after 8 weeks of NAC treatment combined with behavioral therapy, the odds of negative urine toxicology were twice higher as compared to placebo [62], while NAC treatment did not change the cannabis craving in these adolescents in a secondary analysis from that clinical trial [63]

Lovestone et al., 2015), suggesting a non-linear dose-response, future studies to examine the effects of tideglusib in patients at earlier stages and to optimize the most effective dose may be warranted