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Mode of action and pharmacogenomic biomarkers for exceptional responders to didemnin B

The majority of piRNAs generated from piRNA clusters include antisense sequences corresponding to transposable element TE mRNAs, which allows them to use base pairing to direct PIWI proteins to their TE targets

In addition to their well-characterized catalytic activity, there is evidence that GST isoenzymes also participate in regulating the expression of mitogen-activated protein kinases, and promote S-glutathionylation of cysteine residues in target proteins (19)