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Handle under controlled conditions with appropriate protective equipment

Laboratory Handling: Follow established laboratory handling procedures when preparing research materials

The weight loss and insulin sensitivity improvements associated with orforglipron would be expected to significantly reduce the risk of progression from prediabetes to overt type 2 diabetes

Additionally, Protein kinase C (PKC) pathway activation can induce insulin receptor substrate 1 (IRS-1) phosphorylation, inhibiting insulin signaling through downstream effectors such as Akt, phosphoinositide 3-kinase (PI3K), and glucose transporter 4 (GLUT-4) (Ritter et al., 2015