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Key insights include a clear correlation between lipophilicity and permeability, removal of positive charge to avoid off-target toxicities, judicious anionic residue placement to enhance solubility/behavior, optimization of C-terminal length/helicity to enhance potency, and optimization of staple type/number to avoid polypharmacology

It has been one of the most extensively studied copper peptides in dermatological and wound biology research, with over 100 published studies examining its effects on extracellular matrix remodeling, collagen synthesis, and tissue signaling

Patients who have previously experienced allergic reactions to GLP-1 receptor agonists or GIP receptor agonists should be evaluated carefully, as cross-reactivity may occur

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doi: 10.1038/s41467-019-09018-y 345 KrugKJaehnigEJSatpathySBlumenbergLKarpovaAAnuragMet al