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doi: 10.1038/ki.2010.348 108

Although most of NAPQI is formed in the liver, the kidney also metabolizes APAP to the toxic metabolite and releases cysteine conjugate of APAP into the bile and blood for further elimination in urine [9]

Pathophysiological Mechanisms of Ocular Nutrition Oxidative Stress and Antioxidant Defense Systems The retinal environment, particularly the macula, exists under conditions of high oxidative stress due to intense light exposure, elevated oxygen consumption, and abundant polyunsaturated fatty acids