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So I hope that answered your question there

The UPR elicits both cytoprotective and cytotoxic signaling cascades, with the latter including cell death and inflammation [reviewed in (Iurlaro and Muoz-Pinedo, 2016)]

Iron metabolism critically intersects with oxidative stress pathways, as iron overload potentiates reactive oxygen species production via Fenton chemistry, which transforms H 2 O 2 into highly destructive hydroxyl radicals (OH) (77, 147, 148)