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TET1 then further oxidizes 5hmC to 5-formylcytosine (5fC), and subsequently, which is subsequently oxidized to 5-carboxylcytosine (5caC) (43)

Disruption of the gut microbial communities in Crohns patients has been previously reported, however, these disruptions may either exacerbate disease pathologies or be a consequence of the chronic gut inflammation arising from genetic abnormalities that result in dysfunctional immune signalling