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He used a wheelchair before age 20

Even though HC can be prevented by Mesna, sometimes, Mesna cannot be enough for all complications

doi: 10.1128/JCM.00035-14 12 ZhangDLiSWangNTanHYZhangZFengY

AQP4 is involved in cell volume control and K + homeostasis (through interaction with other membrane proteins 575,576 ) and appears to be pro-inflammatory in different experimental models of neurological disease 577,578