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The lysed cell suspension was then centrifuged at 208,000 rcf for 45 minutes, and the supernatant was separated and filtered using a 0.45-m filter

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Changes in polyglutamylation of MTX ( C ) can reduce cellular sensitivity to this drug as MTX and its polyglutamates inhibit the enzyme dihydrofolate reductase (DHFR), causing a block in the conversion of dihydrofolate (FH 2 ) to tetrahydrofolate (FH 4 ), which ultimately results in a reduction in DNA synthesis and cell death

doi: 10.4161/15548627.2014.981788 244 YangSWangXContinoGLiesaMSahinEYingHet al

This study was supported by the National Natural Science Foundation of China (Grant Number: 82270836)