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By identifying common dysregulated pathways across these conditions, we can gain insights into the complex pathophysiology underlying symptoms such as fatigue, PEM and postural orthostatic tachycardia syndrome (POTS)

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Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction

Moreover, GO sheets carry negative charges from ionized functional groups like carboxyl and hydroxyl, creating opportunities for electrostatic interactions with positively charged ions or molecules such as metal ions and industrial cationic dyes like methylene blue (MB) 122,159

It is plausible that both routes operate in parallel, with spatial, temporal, and metabolite-specific dynamics shaping functional outcomes