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The researchers used both in vitro cell culture (HaCaT keratinocytes and primary human dermal papilla cells) and in vivo mouse models

From Rat Studies to Human Extrapolation From rat studies, the remarkably consistent effective dose range of 0.0045 mg/lb to 0.0000045 mg/lb intraperitoneally (a 1000-fold range showing similar efficacy) worked across depression, anxiety, Parkinsons, stroke, schizophrenia, and seizure models

Below that shared point, the two diverge completely